*For a full list of published work, visit Robert M. Buchanan on Google Scholar.



Grants

Thiosemicarbazone based materials a ligand-centered electrocatalysts: A new approach to hydrogen evolution, NSF, $477,477, July 1, 2018-June 30, 2023, PCF# OGMB170515, 1% A, 45.5% 2 summer months, PI (with Gautam Gupta Co-PI), NCE

 

Novel copper complexes as cancer-selective therapeutics, NIH KYNETIC Cycle 5,

$40,625, 7/2022-12/2022 PCF# OGMB 230075 (2%) (Buchanan Co-PI with Beverly PI)

 

Novel copper complexes as cancer-selective therapeutics, NIH KYNETIC Cycle 6,

$40,625, 1/2023-6/2023 PCF# OGMB (2%) (Buchanan Co-PI with Beverly PI)

 

MRI: Acquisition of a Variable Temperature Electron Paramagnetic Resonance (EPR)   Spectrometer, (Grapperhaus PI and Buchanan participant) PCF OGMB 220522, $199,999, NSF, 08/2022-07/2025.

 

Beyond CuATSM: Novel copper complexes for improved ALS therapy, $928,649, USAMRAA (AL220129), 9/1/23 – 8/31/25 (Beverly (PI), Buchanan (Co-PI).

 

Patents

Production of hydrogen peroxide. M. S. Wrighton, R. M. Buchanan, G. C. Calabrese, 1985, US Patent 4,533,443.


Production of hydrogen peroxide. M. S. Wrighton, R. M. Buchanan, G. C. Calabrese, 1985, US Patent 4,576,756.


Apparatus for the production of hydrogen peroxide. M. S. Wrighton, R. M. Buchanan, G. S. Calabrese 1986 US Patent 4,572,774.


Compounds, their preparation, related compositions, catalysts, electrochemical cells, fuel cells, and uses thereof.  Grapperhaus, C. A.; Buchanan, R. M.; Haddad, A. Z.; Calvary, C. A. U.S. Patent 11,142,835. Awarded in 2021.


Compounds, compositions, methods for treating diseases, and methods for preparing compounds. Grapperhaus, C.  A.; Buchanan, R. M.; Vishnosky, N. S.; Young, J. O. E.; Bates, P. J.; Andres, Sarah A.; Calvary, C. A. U.S. Patent 11,142,835. Awarded in 2021.


Methods For The Reduction Of Carbon Dioxide. Grapperhaus, C. A.; Buchanan, R. M.; Cronin, S. P.; Spurgeon, J. M.; Strain, J. M. U.S. Patent 11,078,148. Awarded in 2021.

 

Recent Review Article:

Bajaj K, Buchanan RM, Grapperhaus CA. “Antifungal activity of thiosemicarbazones, bis(thiosemi-carbazones), and their metal complexes.” J Inorg Biochem. 2021 Dec;225:111620. doi: 10.1016/j.jinorgbio.2021.111620.


Citations Associated with Funded Projects:

A.Z. Haddad, B. D. Garabato, P. M. Kozlowski, R. M. Buchanan, C. A. Grapperhaus “Beyond Metal-Hydrides: Non-Transition Metal and Metal-Free Ligand-Centered Electrocatalytic Hydrogen Evolution and Hydrogen Oxidation,” Journal of the American Chemical Society, 2016, 138, 7844-7847. doi: 10.1021/jacs.6b04441.

A. Z. Haddad, S. P. Cronin, M. S. Mashuta, R. M. Buchanan, and C. A. Grapperhaus “Metal-Assisted Ligand-Centered Electrocatalytic Hydrogen Evolution upon Reduction Bis(thiosemicarbazonato)Cu(II) Complex” Inorganic Chemistry 2017, 56, 11254−11265. doi: 10.1021/acs.inorgchem.7b01608.

N. S. Vishnosky, M. S. Mashuta, R. M. Buchanan, C. A. Grapperhaus “Synthesis, structures, and electrochemical stidies of N,N’-bis(alkylthiocarbamate)butane-2,3-dimine Cu(II) complexes as pendent alkoxy derivatives of Cu(ATSM)” Inorganica Chimica Acta, 2017, 461, 45-51. doi: 10.1016/j.ica.2017.02.003.

R. Jain, M. S. Mashuta, R. M. Buchanan, C. A. Grapperhaus, “Electrocatalytic Hydrogen Evolution and Hydrogen Oxidation with a Ni(PS)2 Complex”, Eur. J. Inorg. Chem., 2017, 31, 3714-3719. doi: 10.1002/ejic.201700590.

R. Jain, A. A. Mamun, R. M. Buchanan, P. M. Kozlowski, C. A. Grapperhaus, “Ligand-assisted metal-centered electrocatalytic hydrogen evolution upon reduction of a bis(thiosemicarbazonato)Ni(II) complex” Inorg. Chem. 2018, 57, 13486–13493. doi: 10.1021/acs.inorgchem.8b02110.

G. Saumya, O. Hietsoi, C.  A. Calvary, J. M. Strain, S. Pishgar, H. C. Brun, C. A. Grapperhaus, R. M. Buchanan and J. M. Spurgeon ”Photocatalytic hydrogen evolution on Si-photocathodes modified with bis(thiosemicarbazonato)nickel(II)/Nafion,” Chem Comm. 2019, 55, 9440-9443. doi: 10.1039/c9cc04117f.

A. Gupta,  N. Vishnosky, O. Hietsoi, Y. Losovyj, J. Strain, J. Spurgeon, M. Mashuta, R. Jain, R. M. Buchanan, G. Gupta, C. Grapperhaus, “Effect of Stacking Interactions on the Translation of Structurally Related Bis-thiosemicarbazone Ni(II) HER Catalysts to Modified Electrode Surfaces,” Inorg. Chem. 2019, 55, 12025-12039. doi: 10.1021/acs.inorgchem.9b01209.

C. A. Calvary,O. Hietsoi, J. M. Strain, M. S. Mashuta, J. M. Spurgeon, and R. M. Buchanan, C. A. Grapperhaus,“Synthesis, Characterization, and HER Activity of Pendant Diamine Derivatives of NiATSM,“ Eur, J. Inorg. Chem. 2019, 3782-3790. Doi: 10.1002/ejic.201900721.

           

S. P. Cronin, A. A. Mamun, M. J. Toda, M. S. Mashuta, Y. Losovyj, P. M. Kozlowski, R. M. Buchanan, C. A. Grapperhaus, “Utilizing Charge Effects and Minimizing Intramolecular Proton Rearrangement to Improve the Overpotential of a Thiosemi-carbazonato Zinc HER Catalyst” Inorg. Chem. 2019, 58, 12986-12997. doi: 10.1021/acs.inorgchem.00121.

 

S. A. Andres, K. Bajaj K, N. S. Vishnosky NS, Peterson MA, Mashuta MS, Buchanan RM, Bates PJ, Grapperhaus CA. Synthesis, Characterization, and Biological Activity of Hybrid Thiosemicarbazone-Alkylthiocarbamate Metal Complexes. Inorg Chem. 2020 Apr 6;59(7):4924-4935. doi: 10.1021/acs.inorgchem.0c00182.

 

S. P. Cronin, A. A. Mamun, M. J. Toda, M. S. Mashuta, Y. Losovyj, P. M. Kozlowski, R. M. Buchanan, C. A. Grapperhaus, "Utilizing Charge Effects and Minimizing Intramolecular Proton Rearrangement to Improve Overpotential of a Thiosemicarbazonato Zinc HER Catalyst" Inorg. Chem., 2019, 58, 12986-12997. doi: 10.1021/acs.inorgchem.9b01912.

 

C. A. Calvary, O. Hietsoi, D. T. Hofsommer, H. C. Brun, A. M. Costello, M. S. Mashuta, J. M. Spurgeon, R. M. Buchanan, C. A. Grapperhaus, "Copper bis(thiosemicarbazone) Complexes with Pendent Polyamines: Effects of Proton Relays and Charged Moieties on Electrocatalytic HER" Eur. J. Inorg. Chem., 2021, 2021, 267-275. doi: 10.1002/ejic.20200077).

 

K. Bajaj, S. A. Andres, D. T. Hofsommer, M. Galib, M. S. Mashuta, B. Narayanan, R. M. Buchanan, P. J. Bates, C. A. Grapperhaus “Investigations of Bis(alkylthiocarbamato)Copper Linkage Isomers” Inorg. Chem. 2022, 61, 7715-7719. DOI:10.1021/acs.inorgchem.2c00371.

C. A. Phipps, D. T. Hofsommer, M. J. Toda, F. Nkurunziza, B. Shah, J. M. Spurgeon, P. M. Kozlowski, R. M. Buchanan, C. A. Grapperhaus “Ligand-centered hydrogen evolution with Ni(II) and Pd(II) DMTH” 2022. doi: 10.1021/acs.inorgchem.2c01326.

Paudel, M, Daniel, B, Arts, AM, Kalbfleish, T., Hofsommer, DT, Grapperhaus, CA, Buchanan, RM, Gupta, G. “Unraveling the potential of disposable and modifiable pencils as catalyst supports for the hydrogen evolution reaction” New J. Chem. 2022, 46, 18832-18838.

Phipps, C. A., Hofsommer, D. T., Zirilli, C. D., Duff, B. G., Mashuta, M. S., Buchanan, R. M., Grapperhaus, C. A. “Metal-ligand cooperativity promotes reversible capture of dilute CO2 as a Zn(II)-methylcarbonate,” Inorg. Chem. 2023, 62, 2751-2759.

 

Baja, K., Andres, S. A., Hoffsommer, D. T., Greene, A. F., Hietosi, O., Mashuta, M. S., Weis, T., Beverly, L. J, Bates, P. J., Buchanan, R. M., Grapperhaus, C. A. “Physical structure of constitutional isomers influences antiproliferation activity of thiosemicarbazone-alkylthiocarbamatr copper complexes,” J. Inorg, Biochem. 2023, 112288.